Oxytocin is one of the few hormones regulated by a positive feedback mechanism. Example of a positive feedback loop in the endocrine system Unlike a negative feedback loop, a positive one is not looking to reach homeostasis (stability). A positive feedback loop in the endocrine system is when release of a hormone initiates actions that lead to an additional release of that hormone. Positive feedback mechanism What is a positive feedback mechanism?Ī positive feedback loop in the endocrine system is more rare, happening for only some hormones. This decreases the production of TSH, so the thyroid gland doesn’t get the message to produce T3/T4. In secondary hypothyroidism, there’s an issue with the pituitary gland. If the thyroid gland is damaged, it can’t play its normal role in this negative feedback loop, and can’t produce T3 and T4 like it should. If there is a problem with the hypothalamus, anterior pituitary gland, or thyroid, then it can cause a problem with the whole system.įor example, in primary hypothyroidism, there’s a problem with the thyroid (often from Hashimoto’s disease). This is how homeostasis is maintained in the body. This causes the anterior pituitary gland to secrete an increased amount of TSH, which causes the thyroid to increase production of T3/T4. If there is not enough T3/T4 in the body, the hypothalamus will increase production of TRH. If it does, the hypothalamus/TRH step is skipped, and the anterior pituitary gland decreases production of TSH, which then causes the thyroid to decrease production of T3/T4.īoth of these scenarios work the opposite way as well. The anterior pituitary gland can also be the one to sense if there’s too much T3 and T4 in the body. This causes the anterior pituitary gland to decrease production of TSH, which causes the thyroid gland to decrease production of T3 and T4. This causes the anterior pituitary gland to produce thyroid-stimulating hormone (TSH), which causes the thyroid gland to produce thyroid hormones T3 and T4.īut if the hypothalamus can sense that there is excess T3 and T4 in the body, it will decrease production of TRH. The hypothalamus produces thyroid-releasing hormone (TRH). Example of a negative feedback loop in the endocrine system The 75° represents your body’s preferred levels of different hormones. The endocrine system works similarly to the thermostat, but with your hormones. This will continue to happen so long as your thermostat is set to 75°. If it gets cooler in the room and drops below 75°, your heat will turn back on to return the room to 75°, then turn off once it succeeds. If you set the thermostat in your home to 75°, your heat will run until your temperature gets to 75°, and then it will turn off. If you have heating in your home, you can set the thermostat to a certain temperature and then your heating systems will kick on to maintain that temperature. You can think of it as your body’s attempt to self-regulate and self-correct. And if there’s not enough of the hormone, the body will increase production of that hormone. If an endocrine gland senses that there is too much of one hormone in the body, it will initiate changes to decrease production of that hormone. Negative feedback mechanism What is a negative feedback mechanism?Ī negative feedback loop is one way that the endocrine system tries to keep homeostasis (stability) in the body.
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